In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
What does it mean if your CD4 count is high?
A higher number indicates a stronger immune system. The CD4 cell count of a person who does not have HIV can be anything between 500 and 1500. People living with HIV who have a CD4 count over 500 are usually in pretty good health.
What does CD4 positive mean?
A CD4 count is used to check the health of the immune system in people infected with HIV (human immunodeficiency virus). HIV attacks and destroys CD4 cells. If too many CD4 cells are lost, your immune system will have trouble fighting off infections.
What should CD4 be?
A normal CD4 count ranges from 500–1,200 cells/mm3 in adults and teens. In general, a normal CD4 count means that your immune system is not yet significantly affected by HIV infection. A low CD4 count indicates that your immune system has been affected by HIV and/or the disease is progressing.
What is CD4 disease?
Introduction. Idiopathic CD4 lymphocytopenia (ICL) is an unusual disease in which there is an unexplained deficit of circulating CD4 T cells, leading to fungal, parasitic, and other serious opportunistic infections.
What is the minimum CD4 count?
A healthy immune system normally has a CD4 count ranging from 500 to 1,600 cells per cubic millimeter of blood (cells/mm3), according to HIV.gov. When a CD4 count is lower than 200 cell/mm3, a person will receive a diagnosis of AIDS.
What is a healthy CD4 percentage?
A CD4% of 29% is about the same as a count of over 500 cells/mm3, but there is a wider range for higher values. The average normal CD4 percentage for someone who is HIV negative is about 40%. The normal range is anywhere from about 25% to 65%.